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Research Papers

Journal Articles

Acute Coronary Syndrome

New Sequential External Counterpulsation for the Treatment of Acute Myocardial Infarction.

Zheng ZS, Yu LQ, Cai SR, Kambic H, Li TM, Ma H, Chen PZ, Huang BJ, Nose Y. Transactions of the American Society of Artificial Internal Organs. 1984 Nov;8(4):470 477.

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Portable Enhanced External Counterpulsation for Acute Coronary Syndrome and Cardiogenic

 A Pilot Study. Cohen J, Grossman W, Michaels AD. Clinical Cardiology. 2007 May;30(5):223-228.

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Portable Enhanced External Counterpulsation for Acute Coronary Syndrome and Cardiogenic Shock: A Pilot Study.

Cohen J, Grossman W, Michaels AD. Clinical Cardiology. 2007 May;30(5):223-228.

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New Sequential External Counterpulsation for the Treatment of Acute Myocardial Infarction.

Zheng ZS, Yu LQ, Cai SR, Kambic H, Li TM, Ma H, Chen PZ, Huang BJ, Nose Y. Transactions of the American Society of Artificial Internal Organs. 1984 Nov;8(4):470 477.

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Acute Hemodynamics

Invasive Left Ventricular Energetics During Enhanced External Counterpulsation


. Michaels AD, Tacy T, Teitel D, Shapiro M, Grossman W. American Journal of Therapeutics. 2009;16:239-246. Jan 13. [Epub

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Pneumatic External Counterpulsation: A New Noninvasive Method to Improve Organ Perfusion

Werner D, Schneider M, Weise M, Nonnast-Daniel B, Daniel WG. American Journal of Cardiology. 1999 Oct 15;84(8):950-952

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Acute Hemodynamic Effects and Angina Improvement with Enhanced External Counterpulsation

T, Lawson WE, Hui JCK, Lang G, Liuzzo J, Cohn PF. Angiology. 2001 Oct;52(10):653-658.

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Left Ventricular Systolic Unloading and Augmentation of Intracoronary Pressure and Doppler Flow During Enhanced External Counterpulsation

. Michaels AD, Accad M, Ports TA, Grossman W. Circulation. 2002 Sep 3;106(10):1237-1242.

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Angiogenesis

Assessment of the effect of external counterpulsation on myocardial adaptive arteriogenesis by invasive functional measurements

— design of the arteriogenesis network trial 2. Nikolaos Pagonas, Wolfgang Utz, Jeanette Schulz-Menger, Andreas Busjahn, Jan Monti, Ludwig Thierfelder, Rainer Dietz, Volker Klauss, Michael Gross, Ivo R. Buschmann, Eva-Elina Buschmann and on behalf of the Arteriogenesis Network (Art.Net.).  International J of Cardiology 2009:12087.

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Angiogenic Effects of Long-term Enhanced External Counterpulsation in a Dog Model of Myocardial Infarction

Wu G, Du Z, Hu C, Zheng Z, Zhan C, Ma H, Fang D, Ahmed KT, Laham RJ, Hui JC, Lawson WE. American Journal of Physiology – Heart and Circulatory Physiology. 2006 Jan;290(1):H248-54.
Epub 2005 Aug 19.
 

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Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation

Noble, LThierfelder10.1(Art.Net.-2 Trial). E E Buschmann, W Utz, N Pagonas, J Schulz-Menger, A Busjahn, J Monti,W Maerz, F, R Dietz, V Klauss, M Gross and I R Buschmann, on behalf of the Arteriogenesis Network (Art. Net).. Eur J Clin Invest 2009. DOI: 111/j.1365-2362.2009.0219

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Anti-Inflammation

Effect of Enhanced External Counterpulsation on Inflammatory Cytokines and Adhesion Molecules in Patients with Angina Pectoris and Angiographic Coronary Artery Disease.

Casey DP, Conti CR, Nichols WW, Choi CY, Khuddus MA, Braith RW. American Journal of Cardiology. 2008 Feb 1;101(3):300-302. Epub 2007 

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Enhanced External Counterpulsation Promotes Growth Cytokines-mediated Myocardial Angiogenesis in a Porcine Model of Hypercholesterolemia.

Luo JY, Wu GF, Xiong Y, Chen GW, Xie Q, Yang DY, He XH, Zhang Y, Liu DH, Wang KJ, Ma H, Zheng ZS, DU ZM. Chinese Medical Journal (Engl). 2009 May 20;122(10):1188-94.

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Effect of Enhanced External Counterpulsation on Inflammatory Cytokines and Adhesion Molecules in Patients with Angina Pectoris and Angiographic Coronary Artery Disease.

Casey DP, Conti CR, Nichols WW, Choi CY, Khuddus MA, Braith RW. American Journal of Cardiology. 2008 Feb 1;101(3):300-302. Epub 2007 Dec 11.

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Enhanced External Counterpulsation Promotes Growth Cytokines-mediated Myocardial Angiogenesis in a Porcine Model of Hypercholesterolemia.

Luo JY, Wu GF, Xiong Y, Chen GW, Xie Q, Yang DY, He XH, Zhang Y, Liu DH, Wang KJ, Ma H, Zheng ZS, DU ZM. Chinese Medical Journal (Engl). 2009 May 20;122(10):1188-94.

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Arterial Stiffness

Enhanced External Counterpulsation Improves Endothelium-Dependent Vasorelaxation in the Carotid Arteries of Hypercholesterolemic

 Tao J, Tu C, Yang Z, Zhang Y, Chung XL, Ma H, Zhen ZS
International Journal of Cardiology. 2005 Nov 23; [Epub ahead of print]

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Enhanced External Counterpulsation Treatment Improves Arterial Wall Properties and Wave Reflection Characteristics in Patients With Refractory Angina.

. Nichols WW, Estrada JC, Braith RW, Owens K, Conti CR. Journal of the American College of Cardiology. 2006 Sep 19;48(6):1209-1215. Epub 2006 Aug 25.

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Enhanced External Counterpulsation Improves Systolic Blood Pressure in Patients with Refractory Angina

Campbell AR, Satran D, Zenovich AG, Campbell KM, Espel JC, Arndt TL, Poulose AK, Boisjolie CR, Juusola K, Bart BA, Henry TD. American Heart Journal. 2008 Dec;156(6):1217-22. Epub 2008 Oct 5.
    
 

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EECP cost effectiveness managing CAD

Comparison of Hemodynamic Effects of Enhanced External Counterpulsation and Intra-Aortic Balloon Pumping in Patients with Acute Myocardial Infarction.

Taguchi I, Ogawa K, Oida A, Abe S, Kaneko N, Saki

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Comparison of Patients Undergoing Enhanced External Counterpulsation and Percutaneous Coronary Intervention for Stable Angina Pectoris

Holubkov R, Kennard ED, Foris JM, Kelsey SF, Soran O, Williams DO, Holmes Jr. DR. American Journal of Cardiology. 2002 May 15;89:1182-1186.

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Comparison of Patients Undergoing Enhanced External Counterpulsation and Spinal Cord Stimulation for Refractory Angina .

. Bondesson S, Pettersson T, Erdling A, Hallberg IR, Wackenfors A, Edvinsson L. Coronary Artery Disease. 2008 Dec;19(8):627-634

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EECP Indian Publications

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EECP text book chapters

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Endothelial Function

Peripheral Endothelial Function is a Primary Clinical Target for Enhanced External Counterpulsation in Patients With Refractory Angina.

. Braith RW, Casey DP, Beck DT, Nichols WW, Choi CY, Khuddus MA, Conti CR. Journal of the American College of Cardiology.2009 Mar:53(10 Suppl A);(1054-276).

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Enhanced External Counterpulsation Improves Endothelial Function in Patients with Symptomatic Coronary Artery Disease.

onetti PO, Barsness GW, Keelan PC, Schnell TI, Pumper GM, Kuvin JT, Schnall RP, Holmes DR, Higano ST, Lerman A. Journal of the American College of Cardiology. 2003 May 21;41(10):1761-1768.

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Successful Treatment of Symptomatic Coronary Endothelial Dysfunction with Enhanced External Counterpulsation.

Bonetti PO, Gadasalli SN, Lerman A, Barsness GW. Mayo Clinic Proceedings. 2004 May;79(5):690-692.

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Long-term Effect of Enhanced External Counterpulsation on Endothelial Function in the Patients with Intractable Angina.

Hashemi M, Hoseinbalam M, Khazaei M. Heart Lung Circulation. 2008 Aug 13. [Epub ahead of print].

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Heart Failure

Effect of Enhanced External Counterpulsation on Clinical Symptoms, Quality of Life, 6-Minute Walking Distance, and Echocardiographic Measurements of Left Ventricular Systolic and Diastolic Function After 35 Days of Treatment and at 1-Year Follow Up in 47 Patients With Chronic Refractory Angina Pectoris

Soran O, Fleishman B, Demarco T, Grossman W, Schn A, Feldman AM.
Congestive Heart Failure. 2002 Jul-Aug;8(4)204-208, 227.

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Benefit and Safety of Enhanced External Counterpulsation in Treating Coronary Artery Disease Patients with a History of Congestive Heart Failure. L

. Lawson WE, Kennard ED, Holubkov R, Kelsey SF, Strobeck JE, Soran O, Feldman AM. Cardiology. 2001;96(2):78-84.

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Angina Patients with Diastolic Versus Systolic Heart Failure Demonstrate Comparable Immediate and One-Year Benefit from Enhanced External Counterpulsation

. Lawson WE, Silver MA, Hui JCK, Kennard ED, Kelsey SF.Journal of Cardiac Failure. 2005 Feb;11(1):61-66.

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Two-Year Clinical Outcomes After Enhanced External Counterpulsation (EECP) Therapy in Patients with Refractory Angina Pectoris and Left Ventricular Dysfunction (Report from The International EECP Patient Registry).

. Soran O, Kennard ED, Kfoury AG, Kelsey SF; IEPR Investigators. American Journal of Cardiology. 2006 Jan 1;97(1):17-20. Epub 2005 Nov 2

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Impact of External Counterpulsation Treatment on Emergency Department Visits and Hospitalizations in Refractory Angina Patients with Left Ventricular Dysfunction.

. Soran O, Kennard ED, Bart BA, Kelsey SF.
Congestive Heart Failure. 2007 Jan-Feb;13(1):36-40
 

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Neurohormonal Activation

Effects of Enhanced External Counterpulsation on Hemodynamics and its Mechanism-Relation to Neurohormonal Factors.

Taguchi I, Ogawa K, Kanaya T, Matsuda R, Kuga H, Nakatsugawa M.
Circulation Journal. 2004 Nov;68(11):1030-1034.

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Effect of External Counterpulsation on Plasma Nitric Oxide and Endothelin-1

Du ZM, Zheng ZS, Michaels AD. American Journal Cardiology.2006 Jul 1;98(1):28-30. Epub 2006 May 3.

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Cyclic GMP Release by Acute Enhanced External Counterpulsation

Levenson J, Pernollet MG, Iliou MC, Devynck MA, Simon A. American Journal Hypertension. 2006 Aug;19(8):867-872.

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Randomized Control trials

The Multicenter Study of Enhanced External Counterpulsation (MUST-EECP): Effect of EECP on Exercise-Induced Myocardial Ischemia and Anginal Episodes

Arora RR, Chou TM, Jain D, Fleishman B, Crawford L, McKiernan T, Nesto R. The Journal of the American College of Cardiology. 1999 Jun;33(7):1833-1840

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Effects of Enhanced External Counterpulsation on Health-Related Quality of Life Continue 12 Months After Treatment: A Substudy of the Multicenter Study of Enhanced External Counterpulsation

. Arora RR, Chou TM, Jain D, Fleishman B, Crawford L, McKiernan T, Nesto R, Ferrans CE, Keller S.
Journal of Investigative Medicine. 2002 Jan;50(1):25-32.

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Treating Heart Failure With Enhanced External Counterpulsation (EECP): Design of the Prospective Evaluation of EECP in Heart Failure (PEECH) Tria

Feldman AM, Silver AM, Francis GS, de Lame P, Parmley WW. Journal of Cardiac Failure. 2005 Apr;11(3):240-245.

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Enhanced External Counterpulsation Improves Exercise Duration and Peak Oxygen Consumption in Older Patients With Heart Failure:

 A Subgroup Analysis of the PEECH Trial. Abbottsmith CW, Chung ES, Varricchione T, de Lame W PA, Silver MA, Francis GS, Feldman AM; Prospective Evaluation of EECP in Congestive Heart Failure (PEECH) Investigators. Congestive Heart Failure. 2006 Nov-Dec;12(6):307-311.

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Enhanced External Counterpulsation Improves Exercise Tolerance in Patients With Chronic Heart Failure

Feldman AM, Silver MA, Francis GS, Abbottsmith CW, Fleishman BL, Soran O, de Lame PA, Varricchione T for the PEECH Investigators. Journal of the American College of Cardiology. 2006 Sep 19;48(6):1199-1206. Epub 2006 Aug 25.

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Refractory Angina

Enhanced External Counterpulsation Improves Exercise Tolerance, Reduces Exercise-Induced Myocardial Ischemia and Improves Left Ventricular Diastolic Filling in Patients with Coronary Artery Disease

Urano H, Ikeda H, Ueno T, Matsumoto T, Murohara T, Imaizumi T. Journal of the American College of Cardiology. 2001 Jan;37(1):93-99. 

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Psychosocial Effects of Enhanced External Counterpulsation in the Angina Patient: A Second Study

Springer S, Fife A, Lawson W, Hui JCK, Jandorf L, Cohn PF, Fricchione G. Psychosomatics. 2001 Mar-Apr;42(2):124-132.

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Enhanced External Counterpulsation Improved Myocardial Perfusion and Coronary Flow Reserve in Patients with Chronic Stable Angina; Evaluation by 13N-Ammonia Positron Emission Tomography.

Masuda D, Nohara R, Hirai T, Kataoka K, Chen LG, Hosokawa R, Inubushi M, Tadamura E, Fujita M, Sasayama S. European Heart Journal. 2001 Aug;22(16):1451-1458.

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Effects of Enhanced External Counterpulsation on Stress Radionuclide Coronary Perfusion and Exercise Capacity in Chronic Stable Angina Pectoris.

Stys TP, Lawson WE, Hui JCK, Fleishman B, Manzo K, Strobeck JE, Tartaglia J, Ramasamy S, Suwita R, Zheng ZS, Liang H, Werner D. American Journal of Cardiology. 2002 Apr 1;89(7):822-824.

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Exercise Capability and Myocardial Perfusion in Chronic Angina Patients Treated with Enhanced External Counterpulsation.

Tartaglia J, Stenerson Jr J, Charney R, Ramasamy S, Fleishman BL, Gerardi P, Hui JCK. Clinical Cardiology. 2003 Jun;(26):287-290.

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refractry angina

Efficacy of Enhanced External Counterpulsation in the Treatment of Angina Pectoris.

, Hui JCK, Soroff HS, Zheng ZS, Kayden DS, Sasvary D, Atkins H, Cohn PF. American Journal of Cardiology. 1992 Oct 1;70(9):859-862.

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Three-Year Sustained Benefit from Enhanced External Counterpulsation in Chronic Angina Pectoris

American Lawson WE, Hui JCK, Zheng ZS, Oster Z, Katz JP, Diggs P, Burger L, Cohn CD, Soroff HS, Cohn PF.
Journal of Cardiology. 1995 Apr 15;75:840-841.
 

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Psychosocial Effects of Enhanced External Counterpulsation in the Angina Patient.

GL, Jaghab K, Lawson W, Hui JCK, Jandorf L, Zheng ZS, Cohn PF, Soroff H. Psychosomatics. 1995 Sep-Oct;36(5):494-497.

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Can Angiographic Findings Predict which Coronary Patients will Benefit from Enhanced External Counterpulsation?

Lawson WE, Hui JCK, Zheng ZS, Burger L, Jiang L, Lillis O, Soroff HS, Cohn PF.
American Journal of Cardiology. 1996 May 15;77(12):1107 1109.

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Improved Exercise Tolerance Following Enhanced External Counterpulsation: Cardiac or Peripheral Effect?

Lawson WE, Hui JCK, Zheng ZS, Burger L, Jiang L, Lillis O, Oster Z, Soroff H, Cohn PF. Cardiology. 1996 Jul-Aug;87(4):271-275.

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